https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Australian general practitioners’ perspectives on integrating specialist diabetes care with primary care: qualitative study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55201 90% of patients annually) and five practices with low rates of monitoring HbA1c levels (< 80% of patients annually) from HNELHD, NSW provided the sampling frame. A total of nine GPs were interviewed. The transcripts from the interviews were reviewed and analysed to identify emergent patterns and themes. Results: Overall, GPs were supportive of DAP. They considered that DAP resulted in significant changes in their knowledge, skills, and approach and improved the quality of diabetes care. Taking a more holistic approach to care, including assessing patients with diabetes for co-morbidities and risk factors that may impact on their future health was also noted. DAP was noted to increase the confidence levels of GPs, which enabled active involvement in the provision of diabetes care rather than referring patients for tertiary specialist care. However, some indicated the program could be time consuming and greater flexibility was needed. Conclusions: GPs reported DAP to benefit their knowledge, skills and approach for managing diabetes. Future research will need to investigate how to improve the intensity and flexibility of the program based on the workload of GPs to ensure long-term acceptability of the program.]]> Wed 24 Apr 2024 13:05:58 AEST ]]> Evaluation of an online intervention for improving stroke survivors’ health-related quality of life: a randomised controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51394 Wed 24 Apr 2024 12:04:11 AEST ]]> Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55374 Wed 22 May 2024 15:07:38 AEST ]]> Endoplasmic reticulum stress enhances the expression of TLR3-induced TSLP by airway epithelium https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55346 Wed 22 May 2024 12:26:00 AEST ]]> A blended face-to-face and smartphone intervention to improve suicide prevention literacy and help-seeking intentions among construction workers: a randomised controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50371 Wed 17 Apr 2024 15:52:35 AEST ]]> Diabetes care practices and outcomes in 40.000 children and adolescents with type 1 diabetes from the SWEET registry during the COVID-19 pandemic https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52328 3 months, aged ≤21 years) for all 4 years from 2018 to 2021. Statistical models were adjusted, among others, for technology use. Results: Sixty-five centers provided telemedicine during COVID-19. Among those centers naive to telemedicine before the pandemic (n = 22), four continued only face-to-face visits. Centers that transitioned partially to telemedicine (n = 32) showed a steady increase in HbA1c between 2018 and 2021 (p < 0.001). Those that transitioned mainly to telemedicine (n = 33 %) improved HbA1c in 2021 compared to 2018 (p < 0.001). Conclusions: Changes to models of care delivery driven by the pandemic showed significant associations with HbA1c shortly after the pandemic outbreak and 2 years of follow-up. The association appeared independent of the concomitant increase in technology use among youth with type 1 diabetes.]]> Wed 17 Apr 2024 15:23:53 AEST ]]> Effect of a polyphenol-rich dietary supplement containing Pinus massoniana bark extract on blood pressure in healthy adults: a parallel, randomized placebo-controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53433 120 mmHg) in the PMBE group reduced by − 6.46 mmHg (p = 0.001) at 12 weeks compared to baseline. No significant changes were reported for individuals with optimal (≤120 mmHg) SBP nor did DBP significantly change in either study groups. In individuals with non-medicated normal-high SBP, SBP significantly reduced by − 7.49 mmHg (p = 0.001) and DBP by − 3.06 mmHg (p = 0.011) at 12 weeks compared to baseline after PMBE. Cross-group comparisons were not statistically different. Conclusions: A polyphenol-rich dietary supplement derived from PMBE led to a clinically and statistically significant reduction in SBP in adults. Future studies to investigate the effects of PMBE-polyphenol supplementation on BP are warranted to confirm and explore optimal dose and impact on hypertension.]]> Wed 17 Apr 2024 14:49:50 AEST ]]> Early access to a cardio-oncology clinic in an Australian context: a qualitative exploration of patient experiences https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53423 Wed 17 Apr 2024 14:39:15 AEST ]]> “You are either with me on this or not”: A meta-ethnography of the influence birth partners and care-providers have on coping strategies learned in childbirth education and used by women during labour https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50368 Wed 17 Apr 2024 14:14:52 AEST ]]> “Sex Should Not Be Part of the Lives of Persons with Disabilities, but They Are Human Beings Too”: Perceptions of Healthcare Providers and Factors Affecting Service Delivery in Ghana https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53236 Wed 17 Apr 2024 13:58:56 AEST ]]> A patient-centred approach to determine optimal supportive care across the cancer trajectory: a cross-sectional study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49045 Wed 17 Apr 2024 13:12:16 AEST ]]> A Novel Vision Transformer Model for Skin Cancer Classification https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53760 Wed 15 May 2024 16:00:49 AEST ]]> A Phase 1 Clinical Trial of the Repurposable Acetyllysine Mimetic, n-methyl-2-pyrrolidone (NMP), in Relapsed or Refractory Multiple Myeloma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50573 30% of patients) of any grade were nausea and musculoskeletal pain. The only dose limiting toxicity (DLT) was diarrhoea in a patient receiving 200 mg NMP (overall DLT rate 8%; 95% CI 0–36%). Hence, the MTD was not defined. Median progression-free and overall survival were 57 (range 29–539) days and 33 (95% CI 9.7– > 44) months, respectively. The best response of stable disease (SD) was achieved in nine patients (69%; 95% CI 39–91%). PK analysis demonstrated proportional dose–concentrations up to 400 mg daily, with a more linear relationship above 500 mg. Maximum plasma concentrations (Cmax) of 16.7 mg/L at the 800 mg dose were below those predicted to inhibit BET-bromodomains. Peripheral blood immune-profiling demonstrated maintenance of natural killer (NK) cells, and a gene expression signature suggestive of enhanced T, B and NK cell functions; a subject with prolonged exposure manifested sustained recovery of B and NK cells at 12 months. Conclusions: NMP demonstrated potential disease stabilising and immunomodulatory activity at sub-BET inhibitory plasma concentrations and was well tolerated in RR–MM; an MTD was not determined up to a maximum dose of 1 g daily. Further dose-finding studies are required to optimise NMP dosing strategies for therapeutic intervention.]]> Wed 15 May 2024 15:53:05 AEST ]]> Radiotherapy quality assurance in the TROG 12.01 randomised trial and its impact on loco-regional failure https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55329 Wed 15 May 2024 15:47:21 AEST ]]> The dynamics of international health system reforms: Evidence of a new wave in response to the 2008 economic crisis and the COVID-19 pandemic? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55331 Wed 15 May 2024 15:46:24 AEST ]]> A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase–mediated tyrosine phosphorylation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51830 Wed 15 May 2024 15:34:41 AEST ]]> A mixed-methods study of the awareness and functionality of sexual and reproductive health services among persons with disability in Ghana https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53572 Wed 15 May 2024 14:51:24 AEST ]]> A mixed methods evaluation of Quit for new life, a smoking cessation initiative for women having an Aboriginal baby https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50696 Wed 15 May 2024 14:51:17 AEST ]]> A Method for Rapid Machine Learning Development for Data Mining with Doctor-inthe- Loop https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50396 Wed 15 May 2024 14:43:57 AEST ]]> Cook like a Boss Online: an adapted intervention during the COVID-19 pandemic that effectively improved children’s perceived cooking competence, movement competence and wellbeing https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51408 Wed 15 May 2024 09:42:31 AEST ]]> Pandemic surveillance and mobilities across Sydney, New South Wales https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54597 Wed 15 May 2024 09:39:11 AEST ]]> Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54592 Wed 15 May 2024 09:23:42 AEST ]]> A High Throughput Approach for Designing Polymers That Mimic the TRAIL Protein https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51014 50 values ∼2 μM and resulted in the elevated levels of caspase-8 expected from this mechanism of cell death. Our results demonstrate the potential for HTP screening methods to be used in the design of polymers that can mimic a whole range of complex therapeutic proteins.]]> Wed 15 May 2024 08:50:44 AEST ]]> The role of the microbiome and the NLRP3 inflammasome in the gut and lung https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42686 Wed 08 May 2024 12:01:18 AEST ]]> Barriers to the implementation of clinical guidelines for maternal alcohol consumption in antenatal services: a survey using the theoretical domains framework https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37483 Wed 08 May 2024 11:18:17 AEST ]]> Convergent and criterion validity of PROMIS anxiety measures relative to six legacy measures and a structured diagnostic interview for anxiety in cancer patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51823 .80) were good for both PROMIS measures and comparable to or better than all legacy measures. At the recommended mild cut-point (55), PROMIS-A-SF had sensitivity (.67) comparable to or better than all the legacy measures, whereas PROMIS-A-CAT sensitivity (.59) was lower than GAD-7 (.67) and HADS-A (.62), but comparable to PSYCH-6 and higher than DASS-A, DASS-S and DT. Sensitivity for both was.79. A reduced cut-point of 51 on both PROMIS measures improved sensitivity (.83–.84) although specificity was only adequate (.61–.62). Conclusions: The convergent and criterion validity of the PROMIS anxiety measures in cancer populations was confirmed as equivalent, but not superior to, established measures (GAD-7 and HADS-A). The PROMIS-A-CAT did not demonstrate clear advantages over PROMIS-A-SF.]]> Wed 08 May 2024 09:59:12 AEST ]]> Human beta-defensin-2 suppresses key features of asthma in murine models of allergic airways disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41553 Wed 08 May 2024 09:45:18 AEST ]]> Patient-Reported Symptom Severity, Health-Related Quality of Life, and Emotional Distress Trajectories During and After Radiation Therapy for Human Papillomavirus–Associated Oropharyngeal Cancer: A TROG 12.01 Secondary Analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55237 Wed 01 May 2024 15:42:40 AEST ]]> A coral disease outbreak highlights vulnerability of remote high-latitude lagoons to global and local stressors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51270 Wed 01 May 2024 15:33:21 AEST ]]> A Composite Serum Biomarker Index for the Diagnosis of Systemic Sclerosis–Associated Interstitial Lung Disease: A Multicenter, Observational Cohort Study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50684 Wed 01 May 2024 15:04:24 AEST ]]> An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44806 Wed 01 May 2024 12:05:04 AEST ]]> Exploring the motivation of health professionals to engage with research at various career stages https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55222 Wed 01 May 2024 10:45:33 AEST ]]> A qualitative study investigating Australian cancer service outpatients’ experience of distress screening and management: what is the personal relevance, acceptability and improvement opportunities from patient perspectives? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47065 Tue 30 Apr 2024 09:57:14 AEST ]]> Whole blood viscosity is associated with baseline cerebral perfusion in acute ischemic stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47058 Tue 30 Apr 2024 09:50:06 AEST ]]> Contents of nutrition care services among pregnant women attending antenatal clinic: an Exit interview https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49175 Tue 30 Apr 2024 09:33:20 AEST ]]> Confocal microscopy, dermoscopy, and histopathology features of atypical intraepidermal melanocytic proliferations associated with evolution to melanoma in situ https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44783 Tue 30 Apr 2024 09:05:42 AEST ]]> Conditionally reprogrammed asthmatic bronchial epithelial cells express lower FOXJ1 at terminal differentiation and lower IFNs following RV-A1 infection https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47290 Tue 30 Apr 2024 08:50:07 AEST ]]> Chemotherapy in patients with unresected pancreatic cancer in Australia: A population-based study of uptake and survival https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43084 Tue 23 Apr 2024 16:00:38 AEST ]]> Advances in Exercise and Nutrition as Therapy in Diabetes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55172 Tue 23 Apr 2024 09:38:58 AEST ]]> Relationship of sputum mast cells with clinical and inflammatory characteristics of asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46094 1 and FVC. Trends towards similar clinical associations with elevated MCs were observed in a paucigranulocytic subpopulation (n = 15) lacking airway eosinophilia or neutrophilia. Receiver operator characteristic (ROC) analysis showed peripheral blood eosinophil (PBE) count predicted elevated sputum eosinophils and basophils, but not MCs. Conclusions and Clinical Relevance: Sputum MCs are elevated in asthma, and their measurement may be useful as they relate to key clinical features of asthma (spirometry, asthma control, AHR). PBE count did not predict airway MC status, suggesting direct measurement of airway MCs by sensitive methods such as flow cytometry should be further developed.]]> Tue 21 May 2024 11:55:14 AEST ]]> Hepatitis C Virus Antiviral Drug Resistance and Salvage Therapy Outcomes Across Australia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55368 Tue 21 May 2024 09:42:55 AEST ]]> Influence of the bile acid/microbiota axis in ileal surgery: a systematic review https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55301 Tue 14 May 2024 17:51:09 AEST ]]> Co-Designed Cardiac Rehabilitation for the Secondary Prevention of Stroke (CARESS): A Pilot Program Evaluation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55298 Tue 14 May 2024 17:50:48 AEST ]]> Factors influencing nursing and allied health recent graduates' rural versus urban preferred principal place of practice: a cross-sectional data linkage study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54576 Tue 14 May 2024 14:50:29 AEST ]]> Exploring the SPHERE nursing and midwifery clinician researcher career pathway: a qualitative study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54575 Tue 14 May 2024 14:40:10 AEST ]]> Bronchiolitis hospital admission in infancy is associated with later preschool ventilation inhomogeneity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54571 Tue 14 May 2024 14:15:56 AEST ]]> Defining the distinct, intrinsic properties of the novel type I interferon, IFNϵ. https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42974 Tue 14 May 2024 11:55:54 AEST ]]> Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the global burden of disease study 2016 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42491 Tue 14 May 2024 10:01:10 AEST ]]> Scoping review of nutrition intervention and dietary assessment studies in Khmer populations living in Cambodia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39346 Tue 14 May 2024 08:37:30 AEST ]]> Impact of weight management nutrition interventions on dietary outcomes in children and adolescents with overweight or obesity: a systematic review with meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41561 Thu 18 Apr 2024 12:30:28 AEST ]]> Sputum transcriptomics implicates increased p38 signalling activity in severe asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46113 n = 12, defined as per GINA criteria), non-severe uncontrolled (n = 21) and controlled asthma (n = 21) and healthy controls (n = 15). Sputum RNA was extracted and transcriptomic profiles were generated (Illumina HumanRef-8 V2) and analysed (GeneSpring). Sputum protein lysates were analysed for p38 activation in a validation study (n = 24 asthma, n = 8 healthy) by western blotting. Results: There were 2166 genes differentially expressed between the four groups. In severe asthma, the expression of 1875, 1308 and 563 genes was altered compared to healthy controls, controlled and uncontrolled asthma, respectively. Of the 1875 genes significantly different to healthy controls, 123 were >2-fold change from which four networks were identified. Thirty genes (>2-fold change) were significantly different in severe asthma compared to both controlled asthma and healthy controls. There was enrichment of genes in the p38 signalling pathway that were associated with severe asthma. Phosphorylation of p38 was increased in a subset of severe asthma samples, correlating with neutrophilic airway inflammation. Conclusion: Severe asthma is associated with substantial differences in sputum gene expression that underlie unique cellular mechanisms. The p38 signalling pathway may be important in the pathogenesis of severe asthma, and future investigations into p38 inhibition are warranted as a ‘non-Th2’ therapeutic option.]]> Thu 18 Apr 2024 11:56:00 AEST ]]> Let's talk about obesity in respiratory disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55339 Thu 16 May 2024 16:37:15 AEST ]]> Reducing maternal mortality in low- and middle-income countries: the Nepalese approach of helicopter retrieval https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55338 Thu 16 May 2024 16:23:05 AEST ]]> Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44508 Thu 16 May 2024 08:36:18 AEST ]]> Determinants of perinatal outcomes in dialyzed and transplanted women in Australia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51367 10-fold higher odds of preterm birth and low birthweight and 1.8- to 4.6-fold increased odds of other adverse outcomes. In transplanted women, mediation analysis revealed that pregnancy-induced hypertension contributed only a modest proportional effect (2.5%–11.2%) on adverse outcomes. Conclusion: Maternal dialysis and transplantation conferred excess perinatal morbidity, particularly for preterm babies, and even in women with good preconception allograft function. Pregnancy-induced hypertension is not the predominant determinant of perinatal morbidity. Preconception counseling of women with kidney disease should encompass discussion of perinatal complications.]]> Thu 02 May 2024 15:48:24 AEST ]]> External validation of prognostic models for chronic kidney disease among type 2 diabetes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47330 Thu 02 May 2024 15:45:08 AEST ]]> Should brachytherapy be added to external beam radiotherapy for prostate cancer? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47327 Thu 02 May 2024 15:29:57 AEST ]]> Improving knowledge, attitudes, and uptake of cervical cancer prevention among female students: A systematic review and meta-analysis of school-based health education https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47322 Thu 02 May 2024 14:42:59 AEST ]]> Comparison of homeless clinic attenders with and without psychotic illness https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55192 Thu 02 May 2024 14:24:21 AEST ]]> Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49117 Thu 02 May 2024 12:18:23 AEST ]]> Cognitive insight, medication adherence and methamphetamine cessation in people enrolled in a pharmacotherapy trial for methamphetamine use https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38081 Mon 29 Apr 2024 13:46:22 AEST ]]> Fusobacterium nucleatum: An Overview of Evidence, Demi-Decadal Trends, and Its Role in Adverse Pregnancy Outcomes and Various Gynecological Diseases, including Cancers https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55419 Mon 27 May 2024 12:18:11 AEST ]]> Calibrated to drive: Measuring self-assessed driving ability and perceived workload after prolonged sitting and sleep restriction https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55413 Mon 27 May 2024 12:18:05 AEST ]]> Emerging contaminants: A One Health perspective https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55404 Mon 27 May 2024 12:04:23 AEST ]]> Impact of testing on sexually transmitted infections among female brothel sex workers in Bangladesh: a randomized controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38992 Mon 22 Apr 2024 15:38:22 AEST ]]> Effectiveness of a practice change intervention in reducing alcohol consumption in pregnant women attending public maternity services https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50983 Mon 22 Apr 2024 15:27:07 AEST ]]> Economic evaluation of a multi-strategy intervention that improves school-based physical activity policy implementation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51124 Mon 22 Apr 2024 15:16:58 AEST ]]> Clinical translation of basic science in asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38612 Mon 22 Apr 2024 15:11:24 AEST ]]> The validity of the state–trait anxiety inventory and the brief scale for anxiety in an inpatient sample with alcohol use disorder https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49042 Mon 22 Apr 2024 14:18:14 AEST ]]> Dental anxiety and oral health following stroke: a pilot study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51208 Mon 22 Apr 2024 14:14:52 AEST ]]> Delayed filling of the superficial middle cerebral vein in acute large artery occlusion https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52319 Mon 22 Apr 2024 14:04:17 AEST ]]> Definition matters: assessment of tolerance to the effects of alcohol in a prospective cohort study of emerging adults https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51177 0.05). Average heavy consumption definitions of tolerance were most strongly associated with persistent AUD (OR = 6.66, P = 0.001; OR = 4.65, P = 0.004) but not associated with new-onset AUD (Ps > 0.05). Conclusions: Initial drink and percentage change thresholds appear to improve the efficacy of change-based tolerance as an indicator for new-onset alcohol use disorder diagnosis in self-report surveys of young adults. When predicting persistent alcohol use disorder, average heavy consumption-based indicators appear to be a better way to measure tolerance than self-reported change-based definitions.]]> Mon 22 Apr 2024 12:31:43 AEST ]]> "There's always something else": patient perspectives on improving the implementation of obesity guidelines in general practice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38207 25), had attended a consultation in the last 6 months and had a diagnosis of at least one of the following: diabetes, kidney disease, hyperlipidemia, hypertension, or cardiovascular disease. Semi-structured telephone interviews were conducted with patients. Interviews were audio-recorded, transcribed verbatim and analysed thematically. Results: While a strong general practitioner (GP)-patient relationship enabled conversation to occur about weight management there was uncertainty as to whether patients or GPs should broach the topic of weight. Patients described complacency regarding their weight and often being unprepared to take up GP advice. Other health issues were felt to take precedence, and patients described inconsistent provision of information and resources to assist them in tackling their weight problems. Conclusions: It is imperative to take into account patient perspectives on obesity management in general practice in order to improve health outcomes. This study provides valuable insights into how PwO can be better managed. Interventions should also include strategies to help patients maintain motivation in making lifestyle changes to support healthy weight loss.]]> Mon 20 May 2024 13:49:47 AEST ]]> A systematic stochastic design strategy achieving an optimal tradeoff between peak BGL and probability of hypoglycaemic events for individuals having type 1 diabetes mellitus https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36297 Mon 15 Apr 2024 10:40:44 AEST ]]> Cost-effectiveness of media reporting guidelines for the prevention of suicide https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51320 Mon 13 May 2024 15:46:39 AEST ]]> Contraceptive use and contraceptive counselling interventions for women of reproductive age with cancer: a systematic review and meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51176 Mon 13 May 2024 15:36:11 AEST ]]> Considerations for Evaluating the Introduction of New Cancer Screening Technology: Use of Interval Cancers to Assess Potential Benefits and Harms https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50771 Mon 13 May 2024 14:09:19 AEST ]]> Cohort profile: A prospective Australian cohort study of women's reproductive characteristics and risk of chronic disease from menarche to premenopause (M-PreM) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52293 Mon 13 May 2024 13:01:48 AEST ]]> Consensus statement on the current pharmacological prevention and management of heart failure https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50853 Mon 13 May 2024 12:58:12 AEST ]]> Clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation (CASSETTE) - An open-labelled pilot randomized controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48189 Mon 13 May 2024 12:49:35 AEST ]]> C5b-9 Membrane Attack Complex Formation and Extracellular Vesicle Shedding in Barrett’s Esophagus and Esophageal Adenocarcinoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51810 Mon 13 May 2024 12:42:49 AEST ]]> Characteristics and service use of NSW Quitline callers with and without mental health conditions https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51350 Mon 13 May 2024 12:41:29 AEST ]]> Do modifiable risk factors for cardiovascular disease post-pregnancy influence the association between hypertensive disorders of pregnancy and cardiovascular health outcomes? A systematic review of observational studies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47031 Mon 13 May 2024 12:26:07 AEST ]]> Burden of five healthcare associated infections in Australia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51469 Mon 13 May 2024 11:58:11 AEST ]]> Nicotinic acid supplementation at a supraphysiological dose increases the bioavailability of NAD+ precursors in mares https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49966 Mon 06 May 2024 15:45:12 AEST ]]> Strategies to improve the implementation of healthy eating, physical activity and obesity prevention policies, practices or programmes within childcare services (Review) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46708 Mon 06 May 2024 15:17:10 AEST ]]> Alcohol use among young Australian adults in May–June 2020 during the COVID-19 pandemic: a prospective cohort study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49927 Mon 06 May 2024 15:16:01 AEST ]]> A cooperative target-fencing protocol of multiple vehicles https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38727 Mon 06 May 2024 14:14:39 AEST ]]> Chronic and Transgenerational Effects of Polystyrene Microplastics at Environmentally Relevant Concentrations in Earthworms (Eisenia fetida) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46934 50% reduction in juvenile production at 0.5% microplastics concentration in soil. Also, significant genotoxicity in terms of DNA damage was observed in the F0 and F1 earthworms. Chemical analysis of microplastic-exposed soils showed the presence of several benzene derivatives that are associated with polystyrene particles. Our study, for the first time to our knowledge, demonstrated the long-term adverse effects on earthworms of polystyrene microplastics even at environmentally relevant concentrations. The results have significant implications for risk assessment of polystyrene microplastics to soil biota.]]> Mon 06 May 2024 14:06:56 AEST ]]> Maternal asthma, breastfeeding, and respiratory outcomes in the first year of life https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40099 χ² tests and logistic regression models, adjusting for confounders, were utilized. Data were complete for 605 participants at T1 and 486 (80%) at T2. Of 605 participants: 89% initiated breastfeeding and 38% breastfed for more than 6 months. Breastfeeding for more than 6 months vs “never” was associated with a reduced adjusted relative risk of infant wheeze at T1 (0.54, 95% confidence interval, 0.30‐0.96). Bronchiolitis risk was reduced at T1 and T2 with more than 6 months of breastfeeding vs “never.” Breastfeeding duration of 1 to 3 months, 4 to 6 months, and more than 6 months were associated with a reduced risk of infant healthcare utilization (all P < .05, vs “never”), but not medication use (P > .05). Breastfeeding for more than 6 months was associated with a reduced risk of wheeze, bronchiolitis, and wheeze‐related healthcare utilization in infants at risk due to maternal asthma. Notably, breastfeeding for shorter durations was associated with a reduced risk of healthcare utilization compared with none. Larger cohorts are needed to further examine the impact of breastfeeding exposure on respiratory health in infants exposed to maternal asthma.]]> Mon 06 May 2024 11:07:39 AEST ]]> Airway and parenchymal transcriptomics in a novel model of asthma and COPD overlap https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48427 Fri 26 Apr 2024 13:31:04 AEST ]]> Nonoperative treatment of multiple rib fractures, the results to beat: International multicenter prospective cohort study among 845 patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55398 Fri 24 May 2024 11:36:24 AEST ]]> Investigating the effects of PFOA accumulation and depuration on specific phospholipids in zebrafish through imaging mass spectrometry https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55357 Fri 17 May 2024 16:04:46 AEST ]]> Experiences and impact of a rural Australian high-risk foot service: A multiple-methods study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55356 Fri 17 May 2024 15:59:09 AEST ]]> Core function in adults with severe asthma and its relationship with breathing symptoms https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55351 r > –0.19; P ≤ .03). Conclusions: Adults with severe asthma have worse core function than their control counterparts, independent of sex. Furthermore, as core function decreases, breathing symptoms increase.]]> Fri 17 May 2024 15:58:53 AEST ]]> Baseline characteristics and ICS/LAMA/LABA response in asthma: analyses from the CAPTAIN study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55350 Fri 17 May 2024 15:57:28 AEST ]]> Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55342 30 mg/d; percent-predicted forced expiratory volume in 1 second [ppFEV1]: <50% to ≥80%). Results: Percentage of biologic responders (ie, those with a category improvement pre- to post-biologic) varied by domain and increased with greater pre-biologic impairment, increasing from 70.2% to 90.0% for exacerbation rate, 46.3% to 52.3% for asthma control, 31.1% to 58.5% for LTOCS daily dose, and 35.8% to 50.6% for ppFEV1. The proportion of patients having improvement post-biologic tended to be greater for anti–IL-5/5R compared with for anti-IgE for exacerbation, asthma control, and ppFEV1 domains, irrespective of pre-biologic impairment. Conclusion: Our results provide realistic outcome-specific post-biologic expectations for both physicians and patients, will be foundational to inform future work on a multidimensional approach to define and assess biologic responders and response, and may enhance appropriate patient selection for biologic therapies. Trial Registration: The ISAR database has ethical approval from the Anonymous Data Ethics Protocols and Transparency (ADEPT) committee (ADEPT0218) and is registered with the European Union Electronic Register of Post-Authorization studies (ENCEPP/DSPP/23720). The study was designed, implemented, and reported in compliance with the European Network Centres for Pharmacoepidemiology and Pharmacovigilance (ENCEPP) Code of Conduct (EUPAS38288) and with all applicable local and international laws and regulation, and registered with ENCEPP (https://www.encepp.eu/encepp/viewResource.htm?id=38289). Governance was provided by ADEPT (registration number: ADEPT1220).]]> Fri 17 May 2024 15:51:09 AEST ]]> Opioid analgesics for nociceptive cancer pain: A comprehensive review https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55344 Fri 17 May 2024 15:50:55 AEST ]]> Availability and readiness of healthcare facilities and their effects on antenatal care services uptake in Bangladesh https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55281 Fri 10 May 2024 16:13:47 AEST ]]> Next Directions in the Neuroscience of Cancers Arising outside the CNS https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55248 Fri 03 May 2024 09:04:54 AEST ]]>